History
The town takes its name from the Letsitele River, whose name is usually translated from Northern Sotho as 'valley of the dead', a reference to the malaria that made the valley deadly until the 1930s. Malaria-control work based at the research station in Tzaneen (later the Siegfried Annecke Research Institute) opened the valley up to farming. The first Crown Grant in the area went to settler E.T. Elliot in the early 1900s on the farm Eiland, and the valley grew into one of the country's leading citrus-export districts.
Getting there
From Tzaneen take the R71 east for about 24 km to the R529 junction, then turn south onto the R529 into Letsitele (roughly 25-30 km in total). From Polokwane it is about 110 km via the R71 over Magoebaskloof and through Tzaneen. From Phalaborwa it is about 75 km west along the R71 past Gravelotte. The R529 also links Letsitele north to Giyani.
Weather & climate
Hot, subtropical Lowveld climate with summer rainfall (mainly November to March) and warm, dry winters. Summers are very hot and humid; winters are mild and sunny. Citrus blossom scents the valley in spring.